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VIAGRA [Sildenafil citrate] An Overview
VIAGRA [Sildenafil citrate] is the only approved and effective oral agent for the treatment of erectile dysfunction. Before that a few lines on erectile dysfunction. Erectile dysfunction [Impotence] is a condition in which erection the penis cannot be achieved during sexual intercourse/masturbation. There are many causes for erectile dysfunction. The most common cause of being increasing age. Other conditions can be: - Diabetes Mellitus - Hypertension - Heart Disease - Atherosclerosis - Lower spinal cord injury - Cancer prostate - Psychogenic - Stress Erection is achieved when there is increased blood flow to penis and hence the main organic cause is disturbance of blood flow to and from the penis. Coming back to VIAGRA [Sildenafil citrate], Viagra is a selective and potent inhibitor of cyclic guanosine monophosphate [cGMP] specific phosphodiesterase type 5 inhibitor [PDE5] which is the predominant phosphodiesterase isoform found in the penis. It is administered in doses of 25, 50 and 100 mg, and enhances erection after sexual stimulation. The onset of action is around 60-90 mins. Sildenafil (compound UK-92,480) was synthesized by a group of chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension and angina pectoris. The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. VIAGRA [Sildenafil citrate] was approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction Reduced initial doses should be considered for patients, who are elderly, have renal insufficiency, or are taking medications that inhibit the CYP3A4 metabolic pathway in the liver [e.g., erythromycin, cimetidine, ketoconazole] as they may increase the serum concentration of sildenafil. The drug does not affect ejaculation, orgasm or sexual drive. When sexual stimulation causes local release of NO, inhibition of PDE5 by VIAGRA [Sildenafil citrate] causes increased levels of cGMP in the corpus cavernosum of the penis resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Side Effects: ?? Headaches ?? Facial flushing ?? ringing in ears, or sudden hearing loss ?? Dyspepsia ?? Nasal congestion. ?? Abnormal vision [blue halo effect] ?? Diarrhea ?? Dizziness ?? Rashes Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss:- Special precautions: In patients with ?? Bleeding disorders such as hemophilia ?? Liver disorder ?? Kidney disorder ?? Active peptic ulcerations and ?? Anatomical deformation of the penis, such as peyronie's disease. ?? Retinitis pigmentosa Contraindications: VIAGRA [Sildenafil citrate], is contraindicated in men receiving nitrate therapy for cardiovascular disease, including agents delivered by oral, sublingual, trans-nasal or topical routes. These agents can potentates its hypotensive effect and may result in profound shock. Viagra should be avoided in patients with congestive heart failure and cardiomyopathy because of the risk of vascular collapse.
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Natural Male Enhancements
treatment for erectile dysfunction available in the market. They claim to cure erectile dysfunction and improve sexual stamina. However, most of these sexual enhancement drugs come with a number of limitations and restrictions and are effective only under certain constrained conditions, taking the spontaneity and impulsiveness out of normal sexual behavior. Almost every erectile enhancement... 
Erectile Dysfunction, also known as Impotence, is a condition which effects many men worldwide with recent figures indicating that the condition can effect as many as 1 out of every 10 men at any given time throughout the course of their lives. As with most medical conditions or ailments, there is not one conclusive underlying cause of the condition but many possible reasons why sexual...
Kamagra is a prescription medicine used to treat the issues related to erectile dysfunction or commonly known as ED in men. Due to vague lifestyle and increased tensions, many people, especially men, are increasingly suffering from a variety of sexual disorders. Impotency, being a permanent sexual disorder, is quite common with men. In order to cure this disease, many doctors and physicians...
Sometimes, however, even a healthy person may have to deal with erectile dysfunction or impotence. Medical drugs specifically targeting your condition can greatly reduce the problem, sometimes all the way to eliminating it. A well chosen erectile dysfunction treatment will improve blood flow in the penile area and increase the working capabilities of the muscles and nerves responsible for the...
Erectile dysfunction also known as impotence is the inability to get or maintain erection firm enough for sexual intercourse. In older men, erectile dysfunction usually has a physical cause like disease, side effects of some drug or injury. Any disorder that reduces the flow of blood in body has potential to cause erectile dysfunction. ED is treatable at any age and various treatment options are...
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